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Analysis of institutional authors

ávila-Román JCorresponding AuthorArreaza-Gil VAuthorCortés-Espinar AjAuthorSoliz-Rueda JrAuthorMulero MAuthorMuguerza BAuthorArola-Arnal AAuthorArola LAuthorTorres-Fuentes CCorresponding Author

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March 23, 2021
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Impact of gut microbiota on plasma oxylipins profile under healthy and obesogenic conditions

Publicated to: Clinical Nutrition. 40 (4): 1475-1486 - 2021-04-01 40(4), DOI: 10.1016/j.clnu.2021.02.035

Authors:

Avila-Román, J; Arreaza-Gil, V; Cortés-Espinar, AJ; Soliz-Rueda, JR; Mulero, M; Muguerza, B; Arola-Arnal, A; Arola, L; Torres-Fuentes, C
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Affiliations

Universitat Rovira i Virgili - Author
‎ Univ Rovira & Virgili, Dept Bioquim & Biotecnol, Nutrigen Res Grp, Tarragona 43007, Spain - Author

Abstract

© 2021 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism Background & aims: Oxylipins (OXLs) are bioactive lipid metabolites derived from polyunsaturated fatty acids (PUFAs) which act as signaling molecules and are involved in inflammatory processes such as those that occur in obesity. On the other hand, gut microbiota plays an essential role in regulating inflammatory responses. However, little is known about the potential impact of gut bacteria on OXLs metabolism. Thus, the objective of this study was to investigate the effect of gut microbiota dysbiosis on plasma oxylipins profile in healthy and diet-induced obese animals. Methods: Eight-week-old male Wistar rats were fed with either a standard or cafeteria diet (CAF) for 5 weeks and administered an antibiotic cocktail (ABX) in the drinking water (Ampicillin: 1 g/ml, Vancomycin: 0.5 g/ml, Imipenem: 0.25 g/ml) for the last 2 weeks in order to induce gut microbiota dysbiosis. Metabolomics analysis of OXLs in plasma was performed by HPLC–MS analysis. No antibiotic treated animals were included as controls. Results: Plasma OXLs profile was significantly altered due to both CAF feeding and ABX administration. ABX effect was more pronounced under obesogenic conditions. Several significant correlations between different bacteria taxa and these lipid mediators were observed. Among these, the positive correlation of Proteobacteria with LTB4, a proinflammatory OXL involved in obesity-related disorders, was especially remarkable. Conclusions: Gut microbiota plays a key role in regulating these lipid metabolites and, therefore, affecting oxylipins-mediated inflammatory processes. These results are the first evidence to our knowledge of gut microbiota impact on OXLs metabolism. Moreover, this can set the basis for developing new obesity markers based on OXLs and gut microbiota profiles.
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Keywords

AccumulationAnimalsAnti-bacterial agentsAntibioticsBacteriaBiomarkersCafeteria dietDietDietary linoleic-acidDisease models, animalDysbiosisGastrointestinal microbiomeGerm-freeGut microbiotaInflammationLipid mediatorsMaleMechanismsMetabolic syndromeMetabolomicsObesityOxylipinsRatsRats, wistarResolution

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Clinical Nutrition due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2021, it was in position 13/90, thus managing to position itself as a Q1 (Primer Cuartil), in the category Nutrition & Dietetics.

From a relative perspective, and based on the normalized impact indicator calculated from World Citations provided by WoS (ESI, Clarivate), it yields a value for the citation normalization relative to the expected citation rate of: 1.26. This indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: ESI Nov 13, 2025)

This information is reinforced by other indicators of the same type, which, although dynamic over time and dependent on the set of average global citations at the time of their calculation, consistently position the work at some point among the top 50% most cited in its field:

  • Weighted Average of Normalized Impact by the Scopus agency: 1.77 (source consulted: FECYT Mar 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2026-01-20, the following number of citations:

  • WoS: 22
  • Scopus: 23
  • Europe PMC: 13
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Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2026-01-20:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 58.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 58 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 13.
  • The number of mentions on the social network X (formerly Twitter): 24 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.
  • Assignment of a Handle/URN as an identifier within the deposit in the Institutional Repository: http://hdl.handle.net/20.500.11797/imarina9173456
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Leadership analysis of institutional authors

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (Ávila Román, Francisco Javier) and Last Author (Torres Fuentes, Cristina).

the authors responsible for correspondence tasks have been Ávila Román, Francisco Javier and Torres Fuentes, Cristina.

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