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Grant support

This work was funded by grants from the Instituto de Salud Carlos III (PI14/00447 and PI17/00879 to JMS and AN) cofunded by the Fondo Europeo de Desarrollo Regional (FEDER; Union Europea, Una manera de hacer Europa), by the Centro de Investigacion Biomedica en Red de Diabetes y Enfermedades Metabolicas Asociadas (CIBERDEM), and by the CERCA Programme and grant 2014_SGR_520 (Generalitat de Catalunya). This work was developed at the Centre Esther Koplowitz.

Analysis of institutional authors

Moreno-Vedia, JuanAuthor

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Article

Alpha1-antitrypsin ameliorates islet amyloid-induced glucose intolerance and (3-cell dysfunction

Publicated to:Molecular Metabolism. 37 100984- - 2020-07-01 37(), DOI: 10.1016/j.molmet.2020.100984

Authors: Rodriguez-Comas, Julia; Moreno-Vedia, Juan; Obach, Merce; Castano, Carlos; de Pablo, Sara; Alcarraz-Vizan, Gema; Diaz-Catalan, Daniela; Mestre, Anna; Horrillo, Raquel; Costa, Montserrat; Novials, Anna; Servitja, Joan-Marc

Affiliations

Ctr Invest Biomed Red Diabet & Enfermedades Metab, Madrid, Spain - Author
Grifols Biosci Res Grp, Barcelona, Spain - Author
Inst Invest Biomed August Pi & Sunyer IDIBAPS, Diabet & Obes Res Lab, Rossello 153,P5, Barcelona 08036, Spain - Author

Abstract

Keywords

ActivationAlpha 1-antitrypsinAlpha1-antitrypsinAmyloidAnimalsAntagonistApoptosisBeta-cell apoptosisBlood glucoseContributesDiabetes mellitus, type 2Disease models, animalGlucoseGlucose intoleranceGlucose tolerance testHumansIappIl-1-betaInflammationInsulinInsulin secretionInsulin-secreting cellsInterleukin-1-betaIslet amyloid polypeptideIslet inflammationIslets of langerhansMacrophageMacrophagesMaleMiceMice, transgenicPolypeptideToxicityΒ-cell

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Molecular Metabolism due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2020, it was in position 16/146, thus managing to position itself as a Q1 (Primer Cuartil), in the category Endocrinology & Metabolism.

From a relative perspective, and based on the normalized impact indicator calculated from the Field Citation Ratio (FCR) of the Dimensions source, it yields a value of: 2.35, which indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: Dimensions Jun 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-06-15, the following number of citations:

  • WoS: 14
  • Scopus: 15
  • Europe PMC: 7
  • OpenCitations: 16

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-06-15:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 31.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 31 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 6.05.
  • The number of mentions on the social network X (formerly Twitter): 10 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.
  • Assignment of a Handle/URN as an identifier within the deposit in the Institutional Repository: http://hdl.handle.net/20.500.11797/imarina9182379