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Analysis of institutional authors

Bravo FiAuthorCalvo EAuthorLópez-Villalba RaAuthorTorres-Fuentes C.AuthorMuguerza BAuthorGarcía-Ruiz ACorresponding AuthorMorales DAuthor

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February 6, 2023
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Valorization of Chicken Slaughterhouse Byproducts to Obtain Antihypertensive Peptides

Publicated to: Nutrients. 15 (2): 457- - 2023-01-01 15(2), DOI: 10.3390/nu15020457

Authors:

Bravo, FI; Calvo, E; López-Villalba, RA; Torres-Fuentes, C; Muguerza, B; García-Ruiz, A; Morales, D
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Affiliations

Univ Rovira & Virgili, Dept Biochem & Biotechnol, Nutrigen Res Grp, Tarragona 43007, Spain - Author
Universitat Rovira i Virgili - Author

Abstract

Hypertension (HTN) is the leading cause of premature deaths worldwide and the main preventable risk factor for cardiovascular diseases. Therefore, there is a current need for new therapeutics to manage this condition. In this regard, protein hydrolysates containing antihypertensive bioactive peptides are of increasing interest. Thus, agri-food industry byproducts have emerged as a valuable source to obtain these hydrolysates as they are rich in proteins and inexpensive. Among these, byproducts from animal origin stand out as they are abundantly generated worldwide. Hence, this review is focused on evaluating the potential role of chicken slaughterhouse byproducts as a source of peptides for managing HTN. Several of these byproducts such as blood, bones, skins, and especially, chicken feet have been used to obtain protein hydrolysates with angiotensin-converting enzyme (ACE)-inhibitory activity and blood pressure-lowering effects. An increase in levels of endogenous antioxidant compounds, a reduction in ACE activity, and an improvement of HTN-associated endothelial dysfunction were the mechanisms underlying their effects. However, most of these studies were carried out in animal models, and further clinical studies are needed in order to confirm these antihypertensive properties. This would increase the value of these byproducts, contributing to the circular economy model of slaughterhouses.
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Keywords

ace-inhibitory activityatherosclerosis riskblood pressurecardiovascular riskcatalyzed plastein reactioncollagen hydrolysatecoronary-heart-diseaseendothelial dysfunctionhydrolysateshypertensionmultifunctional ingredientprotein hydrolysateAbattoirsAngiotensin-converting enzyme inhibitorsAngiotensin-converting enzyme-inhibitory activityAnimalsAntihypertensive agentsBlood pressureChickensEndothelial dysfunctionHydrolysatesHypertensionI-converting-enzymePeptidesProtein hydrolysates

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Nutrients due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2023, it was in position 18/114, thus managing to position itself as a Q1 (Primer Cuartil), in the category Nutrition & Dietetics.

From a relative perspective, and based on the normalized impact indicator calculated from World Citations provided by WoS (ESI, Clarivate), it yields a value for the citation normalization relative to the expected citation rate of: 3.29. This indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: ESI Nov 13, 2025)

This information is reinforced by other indicators of the same type, which, although dynamic over time and dependent on the set of average global citations at the time of their calculation, consistently position the work at some point among the top 50% most cited in its field:

  • Weighted Average of Normalized Impact by the Scopus agency: 2.96 (source consulted: FECYT Mar 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2026-04-25, the following number of citations:

  • WoS: 19
  • Scopus: 21
  • Europe PMC: 7
  • Google Scholar: 20
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Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2026-04-25:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 62.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 59 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 1.
  • The number of mentions on the social network X (formerly Twitter): 2 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.
  • Assignment of a Handle/URN as an identifier within the deposit in the Institutional Repository: http://hdl.handle.net/20.500.11797/imarina9291517
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Leadership analysis of institutional authors

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (Bravo Vázquez, Francisca Isabel) and Last Author (Morales Hernández, Diego).

the author responsible for correspondence tasks has been García Ruiz, Almudena.

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