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Analysis of institutional authors

Gomez, JosepAuthorBodi, MariaAuthorRodriguez, AlejandroCorresponding Author

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A Real-World Data Observational Analysis of the Impact of Liposomal Amphotericin B on Renal Function Using Machine Learning in Critically Ill Patients

Publicated to:Antibiotics. 13 (8): 760- - 2024-08-01 13(8), DOI: 10.3390/antibiotics13080760

Authors: Sacanella, Ignasi; Esteve-Pitarch, Erika; Guevara-Chaux, Jessica; Berrueta, Julen; Garcia-Martinez, Alejandro; Gomez, Josep; Casarino, Cecilia; Ales, Florencia; Canadell, Laura; Martin-Loeches, Ignacio; Grau, Santiago; Candel, Francisco Javier; Bodi, Maria; Rodriguez, Alejandro

Affiliations

Ctr Biomed Res Network Resp Dis CIBERES, Tarragona 43005, Spain - Author
Fdn Univ Ciencias Salud, Fac Med, Postgrad Med Crit & Cuidado Intens, Cra 54 67A-80, Bogota 111221, Colombia - Author
Hosp Clin Univ San Carlos, Clin Microbiol & Infect Dis Dept, Madrid 28040, Spain - Author
Hosp Dr Alejandro Gutierrez, Internal Med Dept, S2600, Venado Tuerto, Argentina - Author
Hosp Mar, Dept Pharm, Barcelona 08003, Spain - Author
Hosp Pediat Garrahan, Dept Pharm, C1245, Buenos Aires, Argentina - Author
Hosp Univ Joan XXIII, Dept Crit Care, Tarragona 43005, Spain - Author
Hosp Univ Joan XXIII, Dept Pharm, Tarragona 43005, Spain - Author
Hosp Univ Joan XXIII, Tech Secretarys Dept, Tarragona 43005, Spain - Author
Pompeu Fabra Univ, Dept Med, Barcelona 08003, Spain - Author
Rovira & Virgili Univ, Pere Virgili Hlth Res Inst, Fac Med, Tarragona 43005, Spain - Author
San Carlos Hosp Hlth Res Inst IdISSC & IML, Madrid 28040, Spain - Author
St James Hosp, Dept Intens Care Med, Multidisciplinary Intens Care Res Org MICRO, Dublin D08 NHY1, Ireland - Author
Tarragona Hlth Data Res Working Grp THeDaR, Tarragona 43005, Spain - Author
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Abstract

Background: Liposomal amphotericin B (L-AmB) has become the mainstay of treatment for severe invasive fungal infections. However, the potential for renal toxicity must be considered. Aims: To evaluate the incidence of acute kidney injury (AKI) in critically ill patients receiving L-AmB for more than 48 h. Methods: Retrospective, observational, single-center study. Clinical, demographic and laboratory variables were obtained automatically from the electronic medical record. AKI incidence was analyzed in the entire population and in patients with a "low" or "high" risk of AKI based on their creatinine levels at the outset of the study. Factors associated with the development of AKI were studied using random forest models. Results: Finally, 67 patients with a median age of 61 (53-71) years, 67% male, a median SOFA of 4 (3-6.5) and a crude mortality of 34.3% were included. No variations in serum creatinine were observed during the observation period, except for a decrease in the high-risk subgroup. A total of 26.8% (total population), 25% (low risk) and 13% (high risk) of patients developed AKI. Norepinephrine, the SOFA score, furosemide (general model), potassium, C-reactive protein and procalcitonin (low-risk subgroup) were the variables identified by the random forest models as important contributing factors to the development of AKI other than L-AmB administration. Conclusions: The development of AKI is multifactorial and the administration of L-AmB appears to be safe in this group of patients.

Keywords

Acute kidney injuryAntifungal agentsCritical careInfectionLipid complexLiposomal amphotericin bMachine learningRandom foresRandom forestScedosporium-prolificansTherap

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Antibiotics due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2024 there are still no calculated indicators, but in 2023, it was in position 26/132, thus managing to position itself as a Q1 (Primer Cuartil), in the category Infectious Diseases.

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-06-17:

  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 8 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

    It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

    • The work has been submitted to a journal whose editorial policy allows open Open Access publication.
    • Assignment of a Handle/URN as an identifier within the deposit in the Institutional Repository: http://hdl.handle.net/20.500.11797/imarina9380974

    Leadership analysis of institutional authors

    This work has been carried out with international collaboration, specifically with researchers from: Argentina; Colombia; United Kingdom.

    There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: Last Author (Rodríguez Oviedo, Alejandro Hugo).

    the author responsible for correspondence tasks has been Rodríguez Oviedo, Alejandro Hugo.