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Analysis of institutional authors

Biosca MAuthorSaltó JAuthorPàmies OCorresponding AuthorDieguez MCorresponding Author

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October 7, 2019
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An improved class of phosphite-oxazoline ligands for Pd-catalyzed allylic substitution reactions

Publicated to: Acs Catalysis. 9 (7): 6033-6048 - 2019-07-05 9(7), DOI: 10.1021/acscatal.9b01166

Authors:

Biosca, Maria; Salto, Joan; Magre, Marc; Norrby, Per-Ola; Pamies, Oscar; Dieguez, Montserrat
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Affiliations

AstraZeneca Gothenburg, R&D BioPharmaceut, Pharmaceut Sci, Data Sci & Modelling, Pepparedsleden 1, S-43150 Molndal, Sweden - Author
AstraZeneca Sweden - Author
Goteborgs Universitet - Author
Univ Gothenburg, Dept Chem & Mol Biol, Kemigarden 4, S-41296 Gothenburg, Sweden - Author
Univ Rovira & Virgili, Dept Quim Fis & Inorgan, C Marcel Li Domingo 1, E-43007 Tarragona, Spain - Author
Universitat Rovira i Virgili - Author
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Abstract

© 2019 American Chemical Society. A method for generation of Pd/phosphite-oxazoline catalysts containing an alkyl backbone chain has been successfully applied to Pd-catalyzed allylic substitution reactions. By carefully selecting the substituents at both the alkyl backbone chain and the oxazoline of the ligand, as well as the configuration of the biaryl phosphite group, high activities (TOF > 8000 mol substrate × (mol Pd × h)−1) and excellent enantioselectivities (ee's up to 99%) have been achieved for many hindered and unhindered substrates with a wide range of C-, O-, and N-nucleophiles (73 substitution products in total). Moreover, DFT and NMR studies of the key Pd-allyl complexes allowed us to better understand the origin of the excellent enantioselectivities observed experimentally. The useful application of the Pd/phosphite-oxazoline catalysts was demonstrated by the syntheses of many chiral carbobicycles, with multiples stereocenters, by simple sequential reactions involving Pd-allylic substitution and either 1,6-enyne cyclization or Pauson−Khand enyne cyclization.
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Keywords

Ab-initioAlkylationAsymmetric allylic substitutionAsymmetric-synthesisBasis-setsCyclobutane backboneDft calculationsEnantioselective allylationForce-field parametersKinetic resolutionMixed pMixed p,n-ligandsModular ligandsMolecular-orbital methodsN-ligandsNmr studyPalladium

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Acs Catalysis due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2019, it was in position 12/159, thus managing to position itself as a Q1 (Primer Cuartil), in the category Chemistry, Physical. Notably, the journal is positioned above the 90th percentile.

Independientemente del impacto esperado determinado por el canal de difusión, es importante destacar el impacto real observado de la propia aportación.

Según las diferentes agencias de indexación, el número de citas acumuladas por esta publicación hasta la fecha 2025-12-27:

  • WoS: 23
  • Scopus: 26
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Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-12-27:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 32.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 32 (PlumX).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

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Leadership analysis of institutional authors

This work has been carried out with international collaboration, specifically with researchers from: Sweden.

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (Biosca Brull, Maria) and Last Author (Diéguez Fernández, Montserrat).

the authors responsible for correspondence tasks have been Pamies Ollé, Oscar and Diéguez Fernández, Montserrat.

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