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Analysis of institutional authors

Santafé Martínez, ManuelAuthorLanuza Escolano, María AngelAuthorGarcia Sancho, Maria De Les NeusAuthorTomás Ferré, José MariaAuthorGarcia NAuthorSalon IAuthorTomàs JAuthor

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June 12, 2020
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Expression of muscarinic acetylcholine receptors (M1-, M2-, M3- and M4-type) in the neuromuscular junction of the newborn and adult rat

Publicated to:Histology And Histopathology. 20 (3): 733-743 - 2005-07-01 20(3), DOI: 10.14670/hh-20.733

Authors: Garcia, N; Santafé, MM; Salon, I; Lanuza, MA; Tomás, J

Affiliations

- Author
Universitat Rovira i Virgili - Author

Abstract

Using intracellular recording and immunohistochemistry, we studied the presynaptic muscarinic autoreceptor subtypes controlling ACh release in the neutomuscular junctions of the newborn (3-6 days postnatal) and adult (30-40 days) rat. In the Levator auris longus muscles of both newborn and adult rats, acetylcholine release was modified by the M1-receptor selective antagonists pirenzepine (10 μM) and MT-7 (100 nM) and by the M2-receptor selective antagonists methoctramine (1 μM) and AF-DX 116 (10 μM). The M4-receptor selective antagonists tropicamide (1 μM) and MT-3 (100 nM) can also modify the neurotransmitter release in certain synapses of the newborn muscles. The neurotransmitter release was not altered by the M3-receptor selective antagonist 4-DAMP (1 μM) in the adult or newborn rats. However, we directly demonstrate by immunocytochemistry the presence of these receptors in the motor endplates and conclude that M1-, M2-, M3- and M4-type muscarinic receptors are present in all the neuromuscular junctions of the rat muscle both in newborn and adult animals. These receptors may be located in the perisynaptic glial cell as well as at the nerve terminals.

Keywords

AutoreceptorsCholinergic synapseMotor nerve

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Histology And Histopathology due to its progression and the good impact it has achieved in recent years, according to the agency Scopus (SJR), it has become a reference in its field. In the year of publication of the work, 2005, it was in position , thus managing to position itself as a Q1 (Primer Cuartil), in the category Pathology and Forensic Medicine.

From a relative perspective, and based on the normalized impact indicator calculated from the Field Citation Ratio (FCR) of the Dimensions source, it yields a value of: 5.2, which indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: Dimensions Jul 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-07-16, the following number of citations:

  • WoS: 55
  • Scopus: 52
  • Europe PMC: 33

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-07-16:

  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 35 (PlumX).

Leadership analysis of institutional authors

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (García Gutiérrez, Nerea) and Last Author (TOMÀS ROIG, JORDI).

the authors responsible for correspondence tasks have been Santafe M and Lanuza M.