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Grant support

This research was funded by Fundacion Seneca-Agencia de Ciencia y Tecnologia de la Region de Murcia, Spain (21969/PI/22); and Grant PID2021-124674NB-I00 funded by MCIN/AEI/10.13039/501100011033 by "ERDF A way of making Europe", by the "European Union".

Analysis of institutional authors

Sanchis, MartaAuthor

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April 17, 2023
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Mucorales and Mucormycosis: Recent Insights and Future Prospects

Publicated to:J Fungi (Basel). 9 (3): - 2023-03-01 9(3), DOI: 10.3390/jof9030335

Authors: Tahiri, Ghizlane; Lax, Carlos; Canovas-Marquez, Jose Tomas; Carrillo-Marin, Pablo; Sanchis, Marta; Navarro, Eusebio; Garre, Victoriano; Nicolas, Francisco Esteban;

Affiliations

Inst Invest Sanitaria Pere Virgili IISPV, Reus 43003, Spain - Author
Univ Murcia, Fac Biol, Dept Genet & Microbiol, Murcia 30100, Spain - Author
Univ Rovira & Virgili, Fac Med & Ciencias Salud, Dept Ciencias Med Basicas, Unidad Microbiol & Microbiol Ambiental, Reus 43003, Spain - Author

Abstract

The classification of Mucorales encompasses a collection of basal fungi that have traditionally demonstrated an aversion to modern genetic manipulation techniques. This aversion led to a scarcity of knowledge regarding their biology compared to other fungal groups. However, the emergence of mucormycosis, a fungal disease caused by Mucorales, has attracted the attention of the clinical field, mainly because available therapies are ineffective for decreasing the fatal outcome associated with the disease. This revitalized curiosity about Mucorales and mucormycosis, also encouraged by the recent COVID-19 pandemic, has spurred a significant and productive effort to uncover their mysteries in recent years. Here, we elaborate on the most remarkable breakthroughs related to the recently discovered genetic advances in Mucorales and mucormycosis. The utilization of a few genetic study models has enabled the identification of virulence factors in Mucorales that were previously described in other pathogens. More notably, recent investigations have identified novel genes and mechanisms controlling the pathogenic potential of Mucorales and their interactions with the host, providing fresh avenues to devise new strategies against mucormycosis. Finally, new study models are allowing virulence studies that were previously hampered in Mucorales, predicting a prolific future for the field.

Keywords

Amphotericin-bAntifungal drug-resistanceAntifungal resistanceAspergillus-fumigatusCarotenogenesisCircinelloidesDimorphismGeneIronMucorMucoralesMucormycosisNegative regulatorRhizopusRhizopus-delemar

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal J Fungi (Basel) due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2023, it was in position 8/33, thus managing to position itself as a Q1 (Primer Cuartil), in the category Mycology.

From a relative perspective, and based on the normalized impact indicator calculated from World Citations from Scopus Elsevier, it yields a value for the Field-Weighted Citation Impact from the Scopus agency: 3.49, which indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: ESI Nov 14, 2024)

This information is reinforced by other indicators of the same type, which, although dynamic over time and dependent on the set of average global citations at the time of their calculation, consistently position the work at some point among the top 50% most cited in its field:

  • Field Citation Ratio (FCR) from Dimensions: 6.83 (source consulted: Dimensions Aug 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-08-02, the following number of citations:

  • Scopus: 15

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-08-02:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 47.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 53 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 3.5.
  • The number of mentions on the social network X (formerly Twitter): 5 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.
  • Assignment of a Handle/URN as an identifier within the deposit in the Institutional Repository: http://hdl.handle.net/20.500.11797/imarina9295562