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Impact on the Sustainable Development Goals (SDGs)

Analysis of institutional authors

Mestres, Helena ClaveroAuthorAuguet, TeresaCorresponding Author

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April 28, 2025
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The Impact of Dietary Interventions on Metabolic Outcomes in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) and Comorbid Conditions, Including Obesity and Type 2 Diabetes

Publicated to: Nutrients. 17 (7): 1257- - 2025-04-03 17(7), DOI: 10.3390/nu17071257

Authors:

Jurek, Joanna Michalina; Zablocka-Sowinska, Katarzyna; Mestres, Helena Clavero; Gutierrez, Leyre Reyes; Camaron, Javier; Auguet, Teresa
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Affiliations

Hosp Univ Tarragona Joan XXIII, Serv Med Interna, Mallafre Guasch 4, Tarragona 43007, Spain - Author
Univ Rovira i Virgili URV, Inst Invest Sanitaria Pere Virgili IISPV, Dept Med & Cirurg, Grp Recerca GEMMAIR AGAUR Med Aplicada URV, Mallafre Guasch 4, Tarragona 43007, Spain - Author
WSB Merito Univ Wroclaw, Fac Finance & Management, PL-53609 Wroclaw, Poland - Author
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Abstract

Background: Metabolic dysfunction-associated steatotic liver disease (MASLD) is a public health concern, linked with immune-metabolic dysfunction. While lifestyle and dietary modifications remain the cornerstone of MASLD management, the optimal dietary approach remains uncertain. Objectives: This systematic review aims to investigate the impact of model dietary patterns on metabolic outcomes in patients with MASLD and evaluate their effects in individuals with coexisting metabolic conditions, such as obesity, metabolic syndrome, and type 2 diabetes mellitus (T2DM). Methods: To conduct the review, PubMed, Scopus, Google Scholar, Cochrane CENTRAL, and ClinicalTrials.gov databases were searched for Randomized Controlled Trials (RCTs) on the adult population, published between January 2019 and September 2024, following PRISMA principles. The quality of the included RCTs was assessed qualitatively based on study characteristics. Results: The main findings of this review demonstrated that the use of interventions with dietary model based on Mediterranean diet (MED) and intermittent fasting (IF) approaches, such as alternative-day fasting (ADF) and time-restricted feeding regimens (TRF) may have potential in reducing body weight, BMI, and waist circumference, with additional benefits of improving glycemic control and reducing inflammation. The effects on hepatic functions, although limited, may be linked with reduced enzyme activity and liver stiffness. Additionally, the use of lacto-ovo-vegetarian diet (LOV-D) and the Dietary Approaches to Stop Hypertension (DASH) diet may offer additional health benefits, including blood pressure management. Conclusions: This review suggests that MED and IF-based strategies may reduce BW, improve glycemic control, and lower inflammation, with potential benefits for hepatic function. Further long-term studies are needed to confirm these effects and underlying mechanisms, which will allow for the optimization of protocols and ensure their safety in MASLD.
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Keywords

AdherenceAdultAdultsComorbidityDash dietDiabetes mellitus, type 2Diet, mediterraneanDietary interventionFastingFatty liverFemaleGood health and well-beingHumansMaleMasld/non-alcoholic fatty liver diseaseMediterraneanMediterranean dietMetabolic outcomesMetabolic syndromeMiddle agedNon-alcoholic fatty liver diseaseObesityRandomized controlled trials as topicRisSystematic revieSystematic reviewType 2 diabetesWeight

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Nutrients due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2025, it was in position 17/113, thus managing to position itself as a Q1 (Primer Cuartil), in the category Nutrition & Dietetics.

Independientemente del impacto esperado determinado por el canal de difusión, es importante destacar el impacto real observado de la propia aportación.

Según las diferentes agencias de indexación, el número de citas acumuladas por esta publicación hasta la fecha 2026-04-05:

  • WoS: 13
  • Scopus: 15
  • Europe PMC: 10
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Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2026-04-05:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 103.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 103 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 58.
  • The number of mentions in news outlets: 6 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.
  • Assignment of a Handle/URN as an identifier within the deposit in the Institutional Repository: http://hdl.handle.net/20.500.11797/imarina9452195
Continuing with the social impact of the work, it is important to emphasize that, due to its content, it can be assigned to the area of interest of ODS 3 - Ensure healthy lives and promote well-being for all at all ages, with a probability of 71% according to the mBERT algorithm developed by Aurora University.
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Leadership analysis of institutional authors

This work has been carried out with international collaboration, specifically with researchers from: Poland.

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (Jurek, Joanna Michalina) and Last Author (Auguet Quintillà, Maria Teresa).

the author responsible for correspondence tasks has been Auguet Quintillà, Maria Teresa.

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Project objectives

Los objetivos perseguidos en esta aportación se centran en analizar el impacto de patrones dietéticos modelo sobre los resultados metabólicos en pacientes con MASLD; evaluar los efectos de dichas intervenciones dietéticas en individuos con comorbilidades metabólicas como obesidad, síndrome metabólico y diabetes tipo 2; determinar la eficacia de dietas específicas como la mediterránea, el ayuno intermitente, la lacto-ovo-vegetariana y DASH en la reducción de peso corporal, índice de masa corporal y circunferencia de cintura; caracterizar la influencia de estas dietas en el control glucémico, la inflamación y la función hepática; y valorar la calidad metodológica de los ensayos clínicos aleatorizados publicados entre enero de 2019 y septiembre de 2024 para fundamentar recomendaciones clínicas.
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Most relevant results

Los resultados más relevantes de esta revisión sistemática sobre intervenciones dietéticas en MASLD y comorbilidades metabólicas incluyen: (1) las dietas basadas en el patrón mediterráneo (MED) y el ayuno intermitente (IF), como el ayuno en días alternos (ADF) y la alimentación restringida en el tiempo (TRF), demostraron reducir el peso corporal, índice de masa corporal y circunferencia de cintura; (2) estas intervenciones también mejoraron el control glucémico y disminuyeron la inflamación; (3) se observaron efectos limitados pero positivos sobre la función hepática, reflejados en la reducción de la actividad enzimática y rigidez hepática; (4) las dietas lacto-ovo-vegetariana (LOV-D) y DASH mostraron beneficios adicionales en el manejo de la presión arterial. Estos hallazgos corresponden a estudios publicados entre enero de 2019 y septiembre de 2024.
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Awards linked to the item

This study has supported by funds from Agencia de Gestio d'Ajuts Universitaris de Recerca (AGAUR-2021-SGR-00030 to Teresa Auguet), and by the INVESTIGO Program from the URV, AGAUR and Plan de Recuperacion, Transformacion y Resiliencia (2023POST-INV-10 to Teresa Auguet).
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