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Analysis of institutional authors

Alemany-Fornes, MarcAuthorMuguerza, BegonaCorresponding AuthorSuarez, ManuelAuthor

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October 15, 2025
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Diamine oxidase deficiency implications for health, current management, and future directions in the treatment of histamine intolerance: A review

Publicated to: International Journal Of Biological Macromolecules. 327 147130- - 2025-10-01 327(), DOI: 10.1016/j.ijbiomac.2025.147130

Authors:

Alemany-Fornes, M; Bori, J; Muguerza, B; Suárez, M
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Affiliations

Ctr Environm Food & Toxicol Technol TecnATox, C Marcelli Domingo 1, Tarragona 43007, Spain - Author
DR Healthcare AB Biotek Hlth, Barcelona 08017, Spain - Author
Inst Hlth Carlos III, CIBERobn Physiopathol Obes & Nutr, Madrid, Spain - Author
Spain Inst Invest Sanitaria Pere Virgili, C Marcelli Domingo 1, Tarragona 43007, Spain - Author
Univ Rovira & Virgili, Dept Bioquim & Biotecnol, Nutrigen Res Grp, Tarragona, Spain - Author
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Abstract

Diamine oxidase (DAO) is a key enzyme responsible for the metabolism of histamine, preventing its excessive accumulation and thereby maintaining physiological homeostasis. When DAO activity is insufficient, histamine intolerance (HIT) arises, manifesting as migraines, gastrointestinal disturbances, and allergy-like reactions, among other disorders. This review provides a comprehensive examination of DAO's biological role and its involvement in pathologies associated with impaired histamine degradation. Moreover, genetic and dietary factors influencing DAO activity are explored, emphasising their significance in histamine metabolism. In addition, it analyses clinical trials assessing the efficacy of DAO supplementation, shedding light on its therapeutic potential. Recent advancements in supplementation strategies are also highlighted, particularly those aimed at mitigating HIT symptoms. Furthermore, this review evaluates DAO-rich supplements in detail, focusing on the intrinsic differences arising from their diverse sources. Lastly, current challenges are discussed, including the lack of standardised diagnostic methods, limitations in supplementation efficacy, and gaps in the regulatory framework. By synthesising current evidence, this review aims to offer insights that guide future research and foster the development of innovative diagnostic and therapeutic strategies for the effective management of histamine intolerance caused by DAO deficiency.
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Keywords

Atopic-dermatitisBacteriaBindingChronic spontaneous urticariaDao activityDao supplementationDiagnosisDrug-drugHeparinHistamineHistamine intoleranceHistidine-decarboxylaseNutritional interventions limitationsPlasma-levelsPurification

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2025, it was in position 6/94, thus managing to position itself as a Q1 (Primer Cuartil), in the category Polymer Science. Notably, the journal is positioned above the 90th percentile.

Independientemente del impacto esperado determinado por el canal de difusión, es importante destacar el impacto real observado de la propia aportación.

Según las diferentes agencias de indexación, el número de citas acumuladas por esta publicación hasta la fecha 2026-04-05:

  • WoS: 1
  • Scopus: 1
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Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2026-04-05:

  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 19 (PlumX).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

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Leadership analysis of institutional authors

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (Alemany Fornes, Marc) and Last Author (Suárez Recio, Manuel).

the author responsible for correspondence tasks has been Muguerza Marquínez, Maria Begoña.

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Awards linked to the item

This work was supported by the Pla de Doctorats Industrials of the Agencia de Gestiod'Ajuts Universitaris i de Recerca (AGAUR) de la Generalitat de Catalunya by grant 2021 DI 00081. M.A.F is a recipient of a predoctoral fellowship from the Pla de Doctorats Industrials.
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